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c17 base dihydro s1p  (Avanti Polar)
93
Avanti Polar c17 base dihydro s1p
C17 Base Dihydro S1p, supplied by Avanti Polar, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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c17 dihydro s1p  (Croda International Plc)
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Croda International Plc c17 dihydro s1p
<t>S1P</t> and Ceramide synthesis and metabolic pathway Ceramide is central hub of sphingolipid metabolism. There is three ways to produce ceramide, one from sphingomyelin (SM) by the action of the sphingomyelinases (SMase), one is the de novo biosynthesis by the action of the serine palmitoyl transferase (SPT) using serine and Palmitoyl-CoA as a substrate, following the production of dihydrosphingosine (dhSph) as an intermediate.dhSph is acylated by the action of ceramide synthase (CERS) to produce dihydroceramide and finally, ceramide is synthesized by the action of desaturase. Another one is salvage pathway by which recycling of free sphingosine produced from the degradation of pre-formed sphingolipids by the action of CERS. Sphingosine is phosphorylated by the enzyme SphKs to produce S1P. S1P plays a various cellular function through its five specific G-protein coupled receptors, i.e. S1P1 and S1P3. Of the S1P receptors, S1P1, S1P2 and S1P3 are expressed in sensory neurons, where S1P1 and S1P3 have been reported to play important roles in regulating nociceptor function. S1P1 and S1P3 are also expressed in both microglia and astrocytes. S1P: sphingosine 1-phosphate, SPPase: sphingosine phosphate phosphatase, SphKs: sphingosine kinases, CerS: ceramide synthase, SMS: SMase: sphingomyelinase SPT: serine palmitoyl transferase.
C17 Dihydro S1p, supplied by Croda International Plc, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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c17 s1p  (Croda International Plc)
93
Croda International Plc c17 s1p
<t>S1P</t> and Ceramide synthesis and metabolic pathway Ceramide is central hub of sphingolipid metabolism. There is three ways to produce ceramide, one from sphingomyelin (SM) by the action of the sphingomyelinases (SMase), one is the de novo biosynthesis by the action of the serine palmitoyl transferase (SPT) using serine and Palmitoyl-CoA as a substrate, following the production of dihydrosphingosine (dhSph) as an intermediate.dhSph is acylated by the action of ceramide synthase (CERS) to produce dihydroceramide and finally, ceramide is synthesized by the action of desaturase. Another one is salvage pathway by which recycling of free sphingosine produced from the degradation of pre-formed sphingolipids by the action of CERS. Sphingosine is phosphorylated by the enzyme SphKs to produce S1P. S1P plays a various cellular function through its five specific G-protein coupled receptors, i.e. S1P1 and S1P3. Of the S1P receptors, S1P1, S1P2 and S1P3 are expressed in sensory neurons, where S1P1 and S1P3 have been reported to play important roles in regulating nociceptor function. S1P1 and S1P3 are also expressed in both microglia and astrocytes. S1P: sphingosine 1-phosphate, SPPase: sphingosine phosphate phosphatase, SphKs: sphingosine kinases, CerS: ceramide synthase, SMS: SMase: sphingomyelinase SPT: serine palmitoyl transferase.
C17 S1p, supplied by Croda International Plc, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/c17 s1p/product/Croda International Plc
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c17 s1p - by Bioz Stars, 2026-03
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c17-base s1p  (Croda International Plc)
90
Croda International Plc c17-base s1p
<t>S1P</t> and Ceramide synthesis and metabolic pathway Ceramide is central hub of sphingolipid metabolism. There is three ways to produce ceramide, one from sphingomyelin (SM) by the action of the sphingomyelinases (SMase), one is the de novo biosynthesis by the action of the serine palmitoyl transferase (SPT) using serine and Palmitoyl-CoA as a substrate, following the production of dihydrosphingosine (dhSph) as an intermediate.dhSph is acylated by the action of ceramide synthase (CERS) to produce dihydroceramide and finally, ceramide is synthesized by the action of desaturase. Another one is salvage pathway by which recycling of free sphingosine produced from the degradation of pre-formed sphingolipids by the action of CERS. Sphingosine is phosphorylated by the enzyme SphKs to produce S1P. S1P plays a various cellular function through its five specific G-protein coupled receptors, i.e. S1P1 and S1P3. Of the S1P receptors, S1P1, S1P2 and S1P3 are expressed in sensory neurons, where S1P1 and S1P3 have been reported to play important roles in regulating nociceptor function. S1P1 and S1P3 are also expressed in both microglia and astrocytes. S1P: sphingosine 1-phosphate, SPPase: sphingosine phosphate phosphatase, SphKs: sphingosine kinases, CerS: ceramide synthase, SMS: SMase: sphingomyelinase SPT: serine palmitoyl transferase.
C17 Base S1p, supplied by Croda International Plc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/c17-base s1p/product/Croda International Plc
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c17-s1p  (Croda International Plc)
90
Croda International Plc c17-s1p
<t>S1P</t> and Ceramide synthesis and metabolic pathway Ceramide is central hub of sphingolipid metabolism. There is three ways to produce ceramide, one from sphingomyelin (SM) by the action of the sphingomyelinases (SMase), one is the de novo biosynthesis by the action of the serine palmitoyl transferase (SPT) using serine and Palmitoyl-CoA as a substrate, following the production of dihydrosphingosine (dhSph) as an intermediate.dhSph is acylated by the action of ceramide synthase (CERS) to produce dihydroceramide and finally, ceramide is synthesized by the action of desaturase. Another one is salvage pathway by which recycling of free sphingosine produced from the degradation of pre-formed sphingolipids by the action of CERS. Sphingosine is phosphorylated by the enzyme SphKs to produce S1P. S1P plays a various cellular function through its five specific G-protein coupled receptors, i.e. S1P1 and S1P3. Of the S1P receptors, S1P1, S1P2 and S1P3 are expressed in sensory neurons, where S1P1 and S1P3 have been reported to play important roles in regulating nociceptor function. S1P1 and S1P3 are also expressed in both microglia and astrocytes. S1P: sphingosine 1-phosphate, SPPase: sphingosine phosphate phosphatase, SphKs: sphingosine kinases, CerS: ceramide synthase, SMS: SMase: sphingomyelinase SPT: serine palmitoyl transferase.
C17 S1p, supplied by Croda International Plc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/c17-s1p/product/Croda International Plc
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c17-s1p - by Bioz Stars, 2026-03
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c17 s1p internal standard (d17:1 s1p  (Croda International Plc)
90
Croda International Plc c17 s1p internal standard (d17:1 s1p
<t>S1P</t> and Ceramide synthesis and metabolic pathway Ceramide is central hub of sphingolipid metabolism. There is three ways to produce ceramide, one from sphingomyelin (SM) by the action of the sphingomyelinases (SMase), one is the de novo biosynthesis by the action of the serine palmitoyl transferase (SPT) using serine and Palmitoyl-CoA as a substrate, following the production of dihydrosphingosine (dhSph) as an intermediate.dhSph is acylated by the action of ceramide synthase (CERS) to produce dihydroceramide and finally, ceramide is synthesized by the action of desaturase. Another one is salvage pathway by which recycling of free sphingosine produced from the degradation of pre-formed sphingolipids by the action of CERS. Sphingosine is phosphorylated by the enzyme SphKs to produce S1P. S1P plays a various cellular function through its five specific G-protein coupled receptors, i.e. S1P1 and S1P3. Of the S1P receptors, S1P1, S1P2 and S1P3 are expressed in sensory neurons, where S1P1 and S1P3 have been reported to play important roles in regulating nociceptor function. S1P1 and S1P3 are also expressed in both microglia and astrocytes. S1P: sphingosine 1-phosphate, SPPase: sphingosine phosphate phosphatase, SphKs: sphingosine kinases, CerS: ceramide synthase, SMS: SMase: sphingomyelinase SPT: serine palmitoyl transferase.
C17 S1p Internal Standard (D17:1 S1p, supplied by Croda International Plc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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c17 s1p internal standard (d17:1 s1p - by Bioz Stars, 2026-03
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c17 base s1p  (Avanti Polar)
96
Avanti Polar c17 base s1p
<t>S1P</t> and Ceramide synthesis and metabolic pathway Ceramide is central hub of sphingolipid metabolism. There is three ways to produce ceramide, one from sphingomyelin (SM) by the action of the sphingomyelinases (SMase), one is the de novo biosynthesis by the action of the serine palmitoyl transferase (SPT) using serine and Palmitoyl-CoA as a substrate, following the production of dihydrosphingosine (dhSph) as an intermediate.dhSph is acylated by the action of ceramide synthase (CERS) to produce dihydroceramide and finally, ceramide is synthesized by the action of desaturase. Another one is salvage pathway by which recycling of free sphingosine produced from the degradation of pre-formed sphingolipids by the action of CERS. Sphingosine is phosphorylated by the enzyme SphKs to produce S1P. S1P plays a various cellular function through its five specific G-protein coupled receptors, i.e. S1P1 and S1P3. Of the S1P receptors, S1P1, S1P2 and S1P3 are expressed in sensory neurons, where S1P1 and S1P3 have been reported to play important roles in regulating nociceptor function. S1P1 and S1P3 are also expressed in both microglia and astrocytes. S1P: sphingosine 1-phosphate, SPPase: sphingosine phosphate phosphatase, SphKs: sphingosine kinases, CerS: ceramide synthase, SMS: SMase: sphingomyelinase SPT: serine palmitoyl transferase.
C17 Base S1p, supplied by Avanti Polar, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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c17 base s1p - by Bioz Stars, 2026-03
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c17 base s1p  (Croda International Plc)
96
Croda International Plc c17 base s1p
<t>S1P</t> and Ceramide synthesis and metabolic pathway Ceramide is central hub of sphingolipid metabolism. There is three ways to produce ceramide, one from sphingomyelin (SM) by the action of the sphingomyelinases (SMase), one is the de novo biosynthesis by the action of the serine palmitoyl transferase (SPT) using serine and Palmitoyl-CoA as a substrate, following the production of dihydrosphingosine (dhSph) as an intermediate.dhSph is acylated by the action of ceramide synthase (CERS) to produce dihydroceramide and finally, ceramide is synthesized by the action of desaturase. Another one is salvage pathway by which recycling of free sphingosine produced from the degradation of pre-formed sphingolipids by the action of CERS. Sphingosine is phosphorylated by the enzyme SphKs to produce S1P. S1P plays a various cellular function through its five specific G-protein coupled receptors, i.e. S1P1 and S1P3. Of the S1P receptors, S1P1, S1P2 and S1P3 are expressed in sensory neurons, where S1P1 and S1P3 have been reported to play important roles in regulating nociceptor function. S1P1 and S1P3 are also expressed in both microglia and astrocytes. S1P: sphingosine 1-phosphate, SPPase: sphingosine phosphate phosphatase, SphKs: sphingosine kinases, CerS: ceramide synthase, SMS: SMase: sphingomyelinase SPT: serine palmitoyl transferase.
C17 Base S1p, supplied by Croda International Plc, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/c17 base s1p/product/Croda International Plc
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c17 base s1p - by Bioz Stars, 2026-03
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c17 base dihydro s1p  (Croda International Plc)
93
Croda International Plc c17 base dihydro s1p
<t>S1P</t> and Ceramide synthesis and metabolic pathway Ceramide is central hub of sphingolipid metabolism. There is three ways to produce ceramide, one from sphingomyelin (SM) by the action of the sphingomyelinases (SMase), one is the de novo biosynthesis by the action of the serine palmitoyl transferase (SPT) using serine and Palmitoyl-CoA as a substrate, following the production of dihydrosphingosine (dhSph) as an intermediate.dhSph is acylated by the action of ceramide synthase (CERS) to produce dihydroceramide and finally, ceramide is synthesized by the action of desaturase. Another one is salvage pathway by which recycling of free sphingosine produced from the degradation of pre-formed sphingolipids by the action of CERS. Sphingosine is phosphorylated by the enzyme SphKs to produce S1P. S1P plays a various cellular function through its five specific G-protein coupled receptors, i.e. S1P1 and S1P3. Of the S1P receptors, S1P1, S1P2 and S1P3 are expressed in sensory neurons, where S1P1 and S1P3 have been reported to play important roles in regulating nociceptor function. S1P1 and S1P3 are also expressed in both microglia and astrocytes. S1P: sphingosine 1-phosphate, SPPase: sphingosine phosphate phosphatase, SphKs: sphingosine kinases, CerS: ceramide synthase, SMS: SMase: sphingomyelinase SPT: serine palmitoyl transferase.
C17 Base Dihydro S1p, supplied by Croda International Plc, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/c17 base dihydro s1p/product/Croda International Plc
Average 93 stars, based on 1 article reviews
c17 base dihydro s1p - by Bioz Stars, 2026-03
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S1P and Ceramide synthesis and metabolic pathway Ceramide is central hub of sphingolipid metabolism. There is three ways to produce ceramide, one from sphingomyelin (SM) by the action of the sphingomyelinases (SMase), one is the de novo biosynthesis by the action of the serine palmitoyl transferase (SPT) using serine and Palmitoyl-CoA as a substrate, following the production of dihydrosphingosine (dhSph) as an intermediate.dhSph is acylated by the action of ceramide synthase (CERS) to produce dihydroceramide and finally, ceramide is synthesized by the action of desaturase. Another one is salvage pathway by which recycling of free sphingosine produced from the degradation of pre-formed sphingolipids by the action of CERS. Sphingosine is phosphorylated by the enzyme SphKs to produce S1P. S1P plays a various cellular function through its five specific G-protein coupled receptors, i.e. S1P1 and S1P3. Of the S1P receptors, S1P1, S1P2 and S1P3 are expressed in sensory neurons, where S1P1 and S1P3 have been reported to play important roles in regulating nociceptor function. S1P1 and S1P3 are also expressed in both microglia and astrocytes. S1P: sphingosine 1-phosphate, SPPase: sphingosine phosphate phosphatase, SphKs: sphingosine kinases, CerS: ceramide synthase, SMS: SMase: sphingomyelinase SPT: serine palmitoyl transferase.

Journal: Biochemistry and Biophysics Reports

Article Title: Metabolism of sphingolipids in a rat spinal cord stenosis model

doi: 10.1016/j.bbrep.2025.102025

Figure Lengend Snippet: S1P and Ceramide synthesis and metabolic pathway Ceramide is central hub of sphingolipid metabolism. There is three ways to produce ceramide, one from sphingomyelin (SM) by the action of the sphingomyelinases (SMase), one is the de novo biosynthesis by the action of the serine palmitoyl transferase (SPT) using serine and Palmitoyl-CoA as a substrate, following the production of dihydrosphingosine (dhSph) as an intermediate.dhSph is acylated by the action of ceramide synthase (CERS) to produce dihydroceramide and finally, ceramide is synthesized by the action of desaturase. Another one is salvage pathway by which recycling of free sphingosine produced from the degradation of pre-formed sphingolipids by the action of CERS. Sphingosine is phosphorylated by the enzyme SphKs to produce S1P. S1P plays a various cellular function through its five specific G-protein coupled receptors, i.e. S1P1 and S1P3. Of the S1P receptors, S1P1, S1P2 and S1P3 are expressed in sensory neurons, where S1P1 and S1P3 have been reported to play important roles in regulating nociceptor function. S1P1 and S1P3 are also expressed in both microglia and astrocytes. S1P: sphingosine 1-phosphate, SPPase: sphingosine phosphate phosphatase, SphKs: sphingosine kinases, CerS: ceramide synthase, SMS: SMase: sphingomyelinase SPT: serine palmitoyl transferase.

Article Snippet: For the internal standards, C17 S1P, C17 dihydro S1P, C17:1 Sphingosine (Sph), C17:1 dihydrosphingosine (dhSph) and d18:1/17:0 Ceramide (Avanti Polar Lipids, Alabama) at 1.0 ng/mL (final concentration) were added.

Techniques: Synthesized, Produced, Cell Function Assay

Quantitative analysis of changes in sphingolipid and ceramide levels over time in the spinal cord tissue subjected to spinal cord compression. Quantitative measurements of A) four sphingolipids (dhSph, dhS1P, Sph, and S1P) and B) six ceramides (Cer16:0, Cer18:0, Cer20:0, Cer22:0, Cer24:0, and Cer24:1) in the spinal cord of naïve rats and rats subjected to silicone compression for 1, 7, and 28 days. n = 4–6. A significant increase in S1P was observed on day 28 compared with the naïve controls. Conversely, the Cer24:1 level tends to increase on day1 and significantly decreased on days 7 and 28 compared to day 1. Statistical analyses were conducted using two-way ANOVA followed by Tukey's multiple comparison test. P < 0.05∗, <0.0001∗∗∗∗.

Journal: Biochemistry and Biophysics Reports

Article Title: Metabolism of sphingolipids in a rat spinal cord stenosis model

doi: 10.1016/j.bbrep.2025.102025

Figure Lengend Snippet: Quantitative analysis of changes in sphingolipid and ceramide levels over time in the spinal cord tissue subjected to spinal cord compression. Quantitative measurements of A) four sphingolipids (dhSph, dhS1P, Sph, and S1P) and B) six ceramides (Cer16:0, Cer18:0, Cer20:0, Cer22:0, Cer24:0, and Cer24:1) in the spinal cord of naïve rats and rats subjected to silicone compression for 1, 7, and 28 days. n = 4–6. A significant increase in S1P was observed on day 28 compared with the naïve controls. Conversely, the Cer24:1 level tends to increase on day1 and significantly decreased on days 7 and 28 compared to day 1. Statistical analyses were conducted using two-way ANOVA followed by Tukey's multiple comparison test. P < 0.05∗, <0.0001∗∗∗∗.

Article Snippet: For the internal standards, C17 S1P, C17 dihydro S1P, C17:1 Sphingosine (Sph), C17:1 dihydrosphingosine (dhSph) and d18:1/17:0 Ceramide (Avanti Polar Lipids, Alabama) at 1.0 ng/mL (final concentration) were added.

Techniques: Comparison

Quantitative analysis of changes in sphingolipid and ceramide levels in cerebrospinal fluid (CSF) subjected to spinal cord compression over time. Quantitative measurements of A) four sphingolipids (dhSph, dhS1P, Sph, and S1P) and B) six ceramides (Cer16:0, Cer18:0, Cer18:1, Cer20:0, Cer22:0, and Cer24:1) in the CSF of naïve rats and rats subjected to spinal cord compression for 1, 7, and 28 days. A significant decrease in Sph was observed on days 1 and 28 compared to the naïve controls. S1P also increased significantly after 7 days. Cer22:0 levels increased on day1, and the Cer24:1 level significantly increased on days 1 and 7 compared to naïve. n = 3–8. Statistical analyses were conducted using two-way ANOVA followed by Tukey's multiple comparison test. P < 0.05∗, <0.0001∗∗∗∗.

Journal: Biochemistry and Biophysics Reports

Article Title: Metabolism of sphingolipids in a rat spinal cord stenosis model

doi: 10.1016/j.bbrep.2025.102025

Figure Lengend Snippet: Quantitative analysis of changes in sphingolipid and ceramide levels in cerebrospinal fluid (CSF) subjected to spinal cord compression over time. Quantitative measurements of A) four sphingolipids (dhSph, dhS1P, Sph, and S1P) and B) six ceramides (Cer16:0, Cer18:0, Cer18:1, Cer20:0, Cer22:0, and Cer24:1) in the CSF of naïve rats and rats subjected to spinal cord compression for 1, 7, and 28 days. A significant decrease in Sph was observed on days 1 and 28 compared to the naïve controls. S1P also increased significantly after 7 days. Cer22:0 levels increased on day1, and the Cer24:1 level significantly increased on days 1 and 7 compared to naïve. n = 3–8. Statistical analyses were conducted using two-way ANOVA followed by Tukey's multiple comparison test. P < 0.05∗, <0.0001∗∗∗∗.

Article Snippet: For the internal standards, C17 S1P, C17 dihydro S1P, C17:1 Sphingosine (Sph), C17:1 dihydrosphingosine (dhSph) and d18:1/17:0 Ceramide (Avanti Polar Lipids, Alabama) at 1.0 ng/mL (final concentration) were added.

Techniques: Comparison

mRNA expression of the G-protein-coupled receptor for S1P (S1P1, S1P3) in the spinal cord after spinal cord compression. Quantitative PCR analysis revealed A) a significant increase in S1P1 mRNA expression throughout the experimental period (days 1, 7, and 28) and B) significant upregulation of S1P3 mRNA expression at day 1. n = 3–6. Statistical analyses were conducted using one-way ANOVA followed by Tukey's multiple comparison test. P < 0.05∗, <0.001∗∗∗.

Journal: Biochemistry and Biophysics Reports

Article Title: Metabolism of sphingolipids in a rat spinal cord stenosis model

doi: 10.1016/j.bbrep.2025.102025

Figure Lengend Snippet: mRNA expression of the G-protein-coupled receptor for S1P (S1P1, S1P3) in the spinal cord after spinal cord compression. Quantitative PCR analysis revealed A) a significant increase in S1P1 mRNA expression throughout the experimental period (days 1, 7, and 28) and B) significant upregulation of S1P3 mRNA expression at day 1. n = 3–6. Statistical analyses were conducted using one-way ANOVA followed by Tukey's multiple comparison test. P < 0.05∗, <0.001∗∗∗.

Article Snippet: For the internal standards, C17 S1P, C17 dihydro S1P, C17:1 Sphingosine (Sph), C17:1 dihydrosphingosine (dhSph) and d18:1/17:0 Ceramide (Avanti Polar Lipids, Alabama) at 1.0 ng/mL (final concentration) were added.

Techniques: Expressing, Real-time Polymerase Chain Reaction, Comparison